科研成果
专利：获授权1项
奖励荣誉：江苏中医药科学技术奖二等奖1项、江苏省医学引进新技术奖二等奖1项、南京市医学新技术奖二等奖1项、南京中医药科学技术奖三等奖1项；
承担科研项目9项，其中国家自然科学基金1项；发表论文30篇，其中SCI18篇，中文核心5篇，科技核心3篇
科研项目
序号 | 项目类型 | 项目名称 | 项目时间 | 经费（万） |
1 | 国家自然科学基金 | 基于MRGPRX2受体途径的甘草抗类过敏活性成分筛选及作用机制探究 | 2020-2022 | 20 |
2 | 江苏省重点研发计划（社会发展）项目 | 基于气-液法类器官培养技术的“扶正”调节结直肠癌免疫微环境科学内涵及临床转化研究 | 2021-2024 | 200 |
3 | 江苏省卫健委医学科研项目 | 甘草“调和诸药”在协同奥沙利铂抗结直肠癌中“减毒增效”的作用及机制研究 | 2025-2027 | 10 |
4 | 江苏省中医药学会雏鹰腾飞项目 | 以四君子汤为例基于类器官/类器官芯片构建中药治疗结直肠癌的多维疗效评价体系 | 2025-2027 | 10 |
5 | 南京中医药大学自然科学基金 | 甘草通过调控PLA2/LPC轴抑制肥大细胞活化缓解奥沙利铂过敏的机制研究 | 2026-2028 | 4 |
代表性论文：
[1] Lu Wang, Binwen Zhou, Jiale Chen, Zhimin Fan, Lina Yin, Xiu Yu, Jinrong Zheng, Xueping Zheng. A Nanosheet-Anchored Hydrogel System: An Injectable Platform for Herbs Polyphenols in Treating Ulcerative Colitis. ACS Appl Mater Interfaces. 2026, 18(4): 6656-6667.
[2] Jingwei Cui, Hao Chen, Yuru Chen, Bingwen Zhou, Chuyue Huang, Pei Wang, Puyang Gong, Zhimin Fan*, Lu Wang*. Licoisoflavone A inhibits colorectal cancer cell proliferation through targeting CDK2-Cyclin E1 axis-mediated cell cycle transition. Biochemical Pharmacology. 2025, 240: 117124.
[3] Chuyue Huang#, Bingwen Zhou#, Meng Duan#, Tuotuo Zheng, Yan Tang, Qingrui Liu, Yujing Dong, Desong Kong, Qiang Leng*, Lu Wang*, Zhimin Fan*. Mechanism of Shi-Yang-Xiao lotion in alleviating perianal eczema based on network pharmacology and experimental validation. Frontiers in Molecular Biosciences. 2025, 2:1621398.
[4] Mangmang Sang#, Yibo Huang#, Lu Wang#, Lei Chen, Nawsherwa, Gang Li, Yan Wang, Xiu Yu, Cuilian Dai, Jinrong Zheng. An “AND” Molecular Logic Gate as a Super-Enhancers for De Novo Designing Activatable Probe and Its Application in Atherosclerosis Imaging, Advanced Science, 2023, 2207066.
[5] Bingwen Zhou#, Qingrui Liu#, Chuyue Huang, Hao Chen, Pei Wang, Yueyang Lu, Shujun Jiang, Desong Kong, Lu Wang*, Zhimin Fan*.Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment. Scientific Reports. 2025, 15(1): 37495.
[6] Lu Wang*, Guizhou Hu, Yin Lu, Shujun Jiang, Jin Qi, Hua Su*. Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx, Chinese Journal of Natural Medicines, 2022, 20(6): 421-431.
[7] Shaohua Xu#, Ruolan Fan#, Lu Wang#, Weishen He. Haixia Ge, Hailan Chen, Wen Xu, Jian Zhang, Wei Xu, Yaqian Feng, Zhimin Fan. Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1): 236-251.